Endocrine Abstracts

Thyroid autoimmunity (TAI) is the most frequent autoimmune disorder in women of childbearing age and increases the risk of thyroid dysfunction. TAI has been shown to be more common in women seeking counselling for infertility. The underlying causal mechanism that may account for any possible detrimental effect of TAI on fertility aspects remains hypothetical. In general, increased levels of anti-thyroid peroxidase abs (TPO-abs) have been defined as the most sensitive marker of...

Screening is a process of identifying apparently healthy people at increased risk of a disease or condition. They can then be offered appropriate treatment to reduce the risk arising from the disease or condition.Thyroid autoimmunity (TAI), defined by the presence of antibodies against thyroperoxidase and thyroglobulin, have been associated with adverse pregnancy outcomes, infertility, and impaired child neurodevelopment. However, associations do not nec...

Autoimmune Addison’s disease (AAD) is widely believed to be associated with total loss of endogenous mineralocorticoid and glucocorticoid production and secretion, due to cell-mediated immune destruction. Therefore, patients with AAD are prescribed lifelong mineralocorticoid and glucocorticoid replacement therapy. We present a case of a 69 year old women known with polyglandular autoimmune disease type 2 (hypothyroidism, Addison’s disease and premature ovarian fail...

Background: Currently, physicians remain uncertain whether to screen and/or treat subclinical thyroid disease. Many observational studies, including cross-sectional, case–control, and prospective cohort studies, have reported on the association between subclinical thyroid disease and an ‘outcome of interest’. All cause mortality, coronary heart disease, fracture risk, and pregnancy outcome may drive the decision to screen or treat subclinical thyroid disease.</p...

Background: Subacute thyroiditis (SAT) is a destructive thyroiditis of probable viral origin. Thyroid dysfunction evolves through a set of stages (hyperthyroidism - hypothyroidism - euthyroidism) and is usually temporary, although some patients develop permanent hypothyroidism. The risk factors for permanent hypothyroidism remain largely unclear.Methods: A retrospective analysis of patients with SAT at the University Hospital of Brussels from 2001-2020 w...

Background: Hypoparathyroidism is a rare endocrine disease with low calcium and insufficient parathyroid hormone levels. In most cases it is caused by thyroid surgery. The objective of this retrospective cohort study was to evaluate if the typical therapy regimens of postsurgical hypoparathyroidism with calcitriol have a negative effect on renal function. Methods: We performed a chart analysis of patients that were seen in a tertiary care hospital in Bru...

Background : The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of an unprecedented scale, with an ever-growing impact on healthcare systems. The clinical presentation of coronavirus disease 2019 (COVID-19) is diverse, ranging from asymptomatic illness to respiratory failure requiring admission to the intensive care unit (ICU). Risk factors for severe presentation include old age, male gender, underlying comorbidities such as metabolic syndr...